Vegf cancer angiogenesis


Angiogenesis - one of the hallmarks of cancer - has emerged as a valid therapeutic target in oncology. The VEGF system represents a key mediator of tumor-initiated angiogenesis and the first target of antiangiogenesis agents introduced in clinical practice. Angiogenesis contributes to several physiological and pathological processes including embryonic development, wound healing, tumor growth and metastasis, rheumatoid arthritis, diabetic retinopathy, atherosclerosis, and revascularization of ischemic myocardium, hind limb muscles, and brain. 1 Lymphangiogenesis is critically important for tumor spread via the lymphatic system. 2,3 The processes of blood and lymphatic angiogenesis are tightly regulated by several key angiogenic factors. Aug 29, 2014 · ABSTRACT: Background Angiogenesis has been recently described as a novel component of inflammatory bowel disease pathogenesis. The level of vascular endothelial growth factor (VEGF) has been found increased in Crohn's disease and ulcerative colitis mucosa. To question whether a pro-inflammatory Escherichia coli could regulate the expression... Pleiotrophin is a potential colorectal cancer prognostic factor that promotes VEGF expression and induces angiogenesis in colorectal cancer. International Journal of Colorectal Disease 2012, 27, 287-298. DOI: 10.1007/s00384-011-1344-z. Yan Xia, Hyun-Kyung Choi, Kyeong Lee. Dec 14, 2001 · Since full-length CTGF specifically inhibited the binding of VEGF 165 to HUVEC and the CTGF deletion mutant lacking the CT domain exhibited inhibition of VEGF 165-induced angiogenesis without any effects on VEGF 121-mediated angiogenesis, it is reasonable to think that the interaction between the TSP-1 domain of CTGF and the exon 7-coded region ...